Smoking alters hydroxyprostaglandin dehydrogenase expression in fetal membranes
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چکیده
منابع مشابه
Regulation of 15-hydroxyprostaglandin dehydrogenase expression in hepatocellular carcinoma.
Cyclooxygenase-2 (COX-2), a rate limiting step in arachidonic acid cascade, plays a key role in the biosynthesis of prostaglandin E2 (PGE2) upon inflammatory stimuli, growth factors, hormones and other cellular stresses. Overproduction of PGE2 stimulates proliferation of various cancer cells, confers resistance to apoptosis and favors metastasis and angiogenesis. The steady-state level of PGE2 ...
متن کاملDecreased Expression of 15-hydroxyprostaglandin Dehydrogenase in Gastric Carcinomas
PURPOSE Gastric carcinoma tissues release high level of prostaglandin E2 (PGE2) when compared to non-neoplastic mucosa, and cyclooxygenase-2 (COX-2), which is the rate-limiting enzyme in prostaglandin (PG) biosynthesis, is often overexpressed in gastric carcinomas and during gastric carcinogenesis. However, little is known about the expression of 15-hydroxyprostaglandin dehydrogenase (15-PGDH),...
متن کاملGenetic Variation in 15-Hydroxyprostaglandin Dehydrogenase and Colon Cancer Susceptibility
BACKGROUND 15-Hydroxyprostaglandin dehydrogenase (15-PGDH) is a metabolic antagonist of COX-2, catalyzing the degradation of inflammation mediator prostaglandin E2 (PGE2) and other prostanoids. Recent studies have established the 15-PGDH gene as a colon cancer suppressor. METHODS We evaluated 15-PDGH as a colon cancer susceptibility locus in a three-stage design. We first genotyped 102 single...
متن کاملDecreased gene expression of 11beta-hydroxysteroid dehydrogenase type 2 and 15-hydroxyprostaglandin dehydrogenase in human placenta of patients with preeclampsia.
Cortisol reduces the activity of the PG-inactivating enzyme 15-hydroxyprostaglandin dehydrogenase (PGDH) in human placental cells. The objective was to investigate a possible relation between 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2), converting cortisol to cortisone, and PGDH gene expression in the placenta of patients with preeclampsia. In placental tissue taken from 20 healthy...
متن کامل15-hydroxyprostaglandin dehydrogenase is down-regulated in gastric cancer.
PURPOSE We have investigated the expression and regulation of 15-hydroxyprostaglandin dehydrogenase (15-PGDH) in gastric cancer. EXPERIMENTAL DESIGN Clinical gastric adenocarcinoma samples were analyzed by immunohistochemistry and quantitative real-time PCR for protein and mRNA expression of 15-PGDH and for methylation status of 15-PGDH promoter. The effects of interleukin-1beta (IL-1beta) an...
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ژورنال
عنوان ژورنال: Reproductive Toxicology
سال: 2018
ISSN: 0890-6238
DOI: 10.1016/j.reprotox.2018.09.004